Addition of deep brain stimulation signal to a local field potential driven Izhikevich model masks the pathological firing pattern of an STN neuron.
Identifieur interne : 002484 ( Main/Exploration ); précédent : 002483; suivant : 002485Addition of deep brain stimulation signal to a local field potential driven Izhikevich model masks the pathological firing pattern of an STN neuron.
Auteurs : Kostis P. Michmizos [Grèce] ; Konstantina S. NikitaSource :
- Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference [ 1557-170X ] ; 2011.
Descripteurs français
- KwdFr :
- Facteurs temps, Humains, Magnétoencéphalographie (), Maladie de Parkinson (physiopathologie), Microélectrodes, Modèles neurologiques, Modèles statistiques, Mâle, Neurones (anatomopathologie), Neurones (physiologie), Noyau subthalamique (physiologie), Potentiels d'action, Stimulation cérébrale profonde (), Sujet âgé, Traitement du signal assisté par ordinateur, Électrodes, Électrophysiologie ().
- MESH :
- anatomopathologie : Neurones.
- physiologie : Neurones, Noyau subthalamique.
- physiopathologie : Maladie de Parkinson.
- Facteurs temps, Humains, Magnétoencéphalographie, Microélectrodes, Modèles neurologiques, Modèles statistiques, Mâle, Potentiels d'action, Stimulation cérébrale profonde, Sujet âgé, Traitement du signal assisté par ordinateur, Électrodes, Électrophysiologie.
English descriptors
- KwdEn :
- Action Potentials, Aged, Deep Brain Stimulation (methods), Electrodes, Electrophysiology (methods), Humans, Magnetoencephalography (methods), Male, Microelectrodes, Models, Neurological, Models, Statistical, Neurons (pathology), Neurons (physiology), Parkinson Disease (physiopathology), Signal Processing, Computer-Assisted, Subthalamic Nucleus (physiology), Time Factors.
- MESH :
- methods : Deep Brain Stimulation, Electrophysiology, Magnetoencephalography.
- pathology : Neurons.
- physiology : Neurons, Subthalamic Nucleus.
- physiopathology : Parkinson Disease.
- Action Potentials, Aged, Electrodes, Humans, Male, Microelectrodes, Models, Neurological, Models, Statistical, Signal Processing, Computer-Assisted, Time Factors.
Abstract
The crucial engagement of the subthalamic nucleus (STN) with the neurosurgical procedure of deep brain stimulation (DBS) that alleviates medically intractable Parkinsonian tremor augments the need to refine our current understanding of STN. To enhance the efficacy of DBS as a result of precise targeting, STN boundaries are accurately mapped using extracellular microelectrode recordings (MERs). We utilized the intranuclear MER to acquire the local field potential (LFP) and drive an Izhikevich model of an STN neuron. Using the model as the test bed for clinically acquired data, we demonstrated that stimulation of the STN neuron produces excitatory responses that tonically increase its average firing rate and alter the pattern of its neuronal activity. We also found that the spiking rhythm increases linearly with the increase of amplitude, frequency, and duration of the DBS pulse, inside the clinical range. Our results are in agreement with the current hypothesis that DBS increases the firing rate of STN and masks its pathological bursting firing pattern.
DOI: 10.1109/IEMBS.2011.6091700
PubMed: 22256022
Affiliations:
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Michmizos</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Simulations and Imaging Laboratory, Faculty of Electrical and Computer Engineering, National Technical University of Athens, 15780 Athens, Greece. konmic@biosim.ntua.gr</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Biomedical Simulations and Imaging Laboratory, Faculty of Electrical and Computer Engineering, National Technical University of Athens, 15780 Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Nikita, Konstantina S" sort="Nikita, Konstantina S" uniqKey="Nikita K" first="Konstantina S" last="Nikita">Konstantina S. Nikita</name></author></analytic><series><title level="j">Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference</title><idno type="ISSN">1557-170X</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Action Potentials</term><term>Aged</term><term>Deep Brain Stimulation (methods)</term><term>Electrodes</term><term>Electrophysiology (methods)</term><term>Humans</term><term>Magnetoencephalography (methods)</term><term>Male</term><term>Microelectrodes</term><term>Models, Neurological</term><term>Models, Statistical</term><term>Neurons (pathology)</term><term>Neurons (physiology)</term><term>Parkinson Disease (physiopathology)</term><term>Signal Processing, Computer-Assisted</term><term>Subthalamic Nucleus (physiology)</term><term>Time Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Facteurs temps</term><term>Humains</term><term>Magnétoencéphalographie ()</term><term>Maladie de Parkinson (physiopathologie)</term><term>Microélectrodes</term><term>Modèles neurologiques</term><term>Modèles statistiques</term><term>Mâle</term><term>Neurones (anatomopathologie)</term><term>Neurones (physiologie)</term><term>Noyau subthalamique (physiologie)</term><term>Potentiels d'action</term><term>Stimulation cérébrale profonde ()</term><term>Sujet âgé</term><term>Traitement du signal assisté par ordinateur</term><term>Électrodes</term><term>Électrophysiologie ()</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Neurones</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term><term>Electrophysiology</term><term>Magnetoencephalography</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Neurones</term><term>Noyau subthalamique</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Neurons</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Maladie de Parkinson</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Action Potentials</term><term>Aged</term><term>Electrodes</term><term>Humans</term><term>Male</term><term>Microelectrodes</term><term>Models, Neurological</term><term>Models, Statistical</term><term>Signal Processing, Computer-Assisted</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Facteurs temps</term><term>Humains</term><term>Magnétoencéphalographie</term><term>Microélectrodes</term><term>Modèles neurologiques</term><term>Modèles statistiques</term><term>Mâle</term><term>Potentiels d'action</term><term>Stimulation cérébrale profonde</term><term>Sujet âgé</term><term>Traitement du signal assisté par ordinateur</term><term>Électrodes</term><term>Électrophysiologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The crucial engagement of the subthalamic nucleus (STN) with the neurosurgical procedure of deep brain stimulation (DBS) that alleviates medically intractable Parkinsonian tremor augments the need to refine our current understanding of STN. To enhance the efficacy of DBS as a result of precise targeting, STN boundaries are accurately mapped using extracellular microelectrode recordings (MERs). We utilized the intranuclear MER to acquire the local field potential (LFP) and drive an Izhikevich model of an STN neuron. Using the model as the test bed for clinically acquired data, we demonstrated that stimulation of the STN neuron produces excitatory responses that tonically increase its average firing rate and alter the pattern of its neuronal activity. We also found that the spiking rhythm increases linearly with the increase of amplitude, frequency, and duration of the DBS pulse, inside the clinical range. Our results are in agreement with the current hypothesis that DBS increases the firing rate of STN and masks its pathological bursting firing pattern.</div></front></TEI><affiliations><list><country><li>Grèce</li></country><region><li>Attique (région)</li></region><settlement><li>Athènes</li></settlement></list><tree><noCountry><name sortKey="Nikita, Konstantina S" sort="Nikita, Konstantina S" uniqKey="Nikita K" first="Konstantina S" last="Nikita">Konstantina S. Nikita</name></noCountry><country name="Grèce"><region name="Attique (région)"><name sortKey="Michmizos, Kostis P" sort="Michmizos, Kostis P" uniqKey="Michmizos K" first="Kostis P" last="Michmizos">Kostis P. Michmizos</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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